Pixar's highly anticipated sequel, "Inside Out 2" has taken over the box office, grossing over 150 million domestically and 295 million worldwide in its first weekend. The animated film, directed by Kelsey Mann, features a star-studded voice cast and offers a deeper look into the mind of the now-teenage protagonist, Riley. This successful opening marks a major comeback for Pixar after struggling with the pandemic's effects on the film industry. With a strong domestic debut and more markets to come, "Inside Out 2" is set to continue its dominance worldwide.